PittsburghV1, France, Analysis, bibRecord, 000271

CIBMTR Chronic GVHD Risk Score Predicts Mortality in an Independent Validation Cohort

Identifieur interne : 000271 ( France/Analysis ); précédent : 000270; suivant : 000272

CIBMTR Chronic GVHD Risk Score Predicts Mortality in an Independent Validation Cohort

Auteurs : Mukta Arora [États-Unis] ; Michael T. Hemmer [États-Unis] ; Kwang Woo Ahn [États-Unis] ; John P. Klein [États-Unis] ; Corey S. Cutler [États-Unis] ; Alvaro Urbano-Ispizua [Espagne] ; Daniel R. Couriel [États-Unis] ; Amin M. Alousi [États-Unis] ; Robert Peter Gale [Royaume-Uni] ; Yoshihiro Inamoto [Japon] ; Daniel J. Weisdorf [États-Unis] ; Peigang Li [États-Unis] ; Joseph H. Antin [États-Unis] ; Brian J. Bolwell [États-Unis] ; Michael Boyiadzis [États-Unis] ; Jean-Yves Cahn [France] ; Mitchell S. Cairo [États-Unis] ; Luis M. Isola [États-Unis] ; David A. Jacobsohn [États-Unis] ; Madan Jagasia [États-Unis] ; Thomas R. Klumpp [États-Unis] ; Effie W. Petersdorf [États-Unis] ; Stella Santarone [Italie] ; Harry C. Schouten [Pays-Bas] ; John R. Wingard [États-Unis] ; Stephen R. Spellman [États-Unis] ; Steven Z. Pavletic [États-Unis] ; Stephanie J. Lee [États-Unis] ; Mary M. Horowitz [États-Unis] ; Mary E. D. Flowers [États-Unis]

Source :

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [ 1083-8791 ] ; 2014.

RBID : PMC:4359642

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Allogreffes, Facteurs de risque, Femelle, Humains, Incidence, Maladie chronique, Maladie du greffon contre l'hôte (mortalité), Mâle, Sujet âgé, Survie sans rechute, Taux de survie, Transplantation de cellules souches hématopoïétiques, Études de cohortes, Études de suivi, Études rétrospectives.
MESH :
- mortalité : Maladie du greffon contre l'hôte.
- Adulte, Adulte d'âge moyen, Allogreffes, Facteurs de risque, Femelle, Humains, Incidence, Maladie chronique, Mâle, Sujet âgé, Survie sans rechute, Taux de survie, Transplantation de cellules souches hématopoïétiques, Études de cohortes, Études de suivi, Études rétrospectives.

English descriptors

KwdEn :
- Adult, Aged, Allografts, Chronic Disease, Cohort Studies, Disease-Free Survival, Female, Follow-Up Studies, Graft vs Host Disease (mortality), Hematopoietic Stem Cell Transplantation, Humans, Incidence, Male, Middle Aged, Retrospective Studies, Risk Factors, Survival Rate.
MESH :
- mortality : Graft vs Host Disease.
- Adult, Aged, Allografts, Chronic Disease, Cohort Studies, Disease-Free Survival, Female, Follow-Up Studies, Hematopoietic Stem Cell Transplantation, Humans, Incidence, Male, Middle Aged, Retrospective Studies, Risk Factors, Survival Rate.

Abstract

We previously reported a risk score that predicted mortality in patients with chronic graft-versus-host disease (CGVHD) after hematopoietic stem cell transplant (HCT) between 1995–2004 and reported to the Center for International Blood and Marrow Transplant Registry (CIBMTR). We sought to validate this risk score in an independent CIBMTR cohort of 1128 patients with CGVHD transplanted between 2005–2007 using the same inclusion criteria and risk-score calculations. According to the sum of the overall risk score (range 1 to 12), patients were assigned to 4 risk-groups (RGs): RG1 (0–2), RG2 (3–6), RG3 (7–8) and RG4 (9–10). RG3 and 4 were combined as RG4 comprised only 1% of the total cohort. Cumulative incidences of non relapse mortality (NRM) and probability of overall survival (OS) were significantly different between each RG (all p<0.01). NRM and OS at five years after CGVHD for each RG were 17% and 72% in RG1, 26% and 53% in RG2, and 44% and 25% in RG 3, respectively (all p<0.01). Our study validates the prognostic value of the CIBMTR CGVHD RGs for OS and NRM in a contemporary transplant population. The CIBMTR CGVHD RGs can be used to predict major outcomes, tailor treatment planning, and enrollment in clinical trials.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359642

DOI: 10.1016/j.bbmt.2014.10.022
PubMed: 25528390
PubMed Central: 4359642

Affiliations:

Espagne, France, Italie, Japon, Pays-Bas, Royaume-Uni, États-Unis
Angleterre, Auvergne-Rhône-Alpes, Catalogne, District de Columbia, Floride, Grand Londres, Maryland, Massachusetts, Michigan, Minnesota, Ohio, Pennsylvanie, Rhône-Alpes, Région de Kantō, Tennessee, Texas, Washington (État), Wisconsin, État de New York
Barcelone, Grenoble, Londres, Tokyo

Links to Exploration step

PMC:4359642

Le document en format XML

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<author><name sortKey="Isola, Luis M" sort="Isola, Luis M" uniqKey="Isola L" first="Luis M." last="Isola">Luis M. Isola</name>
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<author><name sortKey="Jacobsohn, David A" sort="Jacobsohn, David A" uniqKey="Jacobsohn D" first="David A." last="Jacobsohn">David A. Jacobsohn</name>
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<placeName><region type="state">District de Columbia</region>
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<author><name sortKey="Jagasia, Madan" sort="Jagasia, Madan" uniqKey="Jagasia M" first="Madan" last="Jagasia">Madan Jagasia</name>
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<placeName><region type="state">Tennessee</region>
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<wicri:cityArea>Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville</wicri:cityArea>
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<author><name sortKey="Klumpp, Thomas R" sort="Klumpp, Thomas R" uniqKey="Klumpp T" first="Thomas R." last="Klumpp">Thomas R. Klumpp</name>
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<author><name sortKey="Petersdorf, Effie W" sort="Petersdorf, Effie W" uniqKey="Petersdorf E" first="Effie W." last="Petersdorf">Effie W. Petersdorf</name>
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<placeName><region type="state">Washington (État)</region>
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<author><name sortKey="Santarone, Stella" sort="Santarone, Stella" uniqKey="Santarone S" first="Stella" last="Santarone">Stella Santarone</name>
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<author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name>
<affiliation wicri:level="1"><nlm:aff id="A20">Department of Hematology, Academische Ziekenhuis Maastricht, Maastricht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Hematology, Academische Ziekenhuis Maastricht, Maastricht</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Wingard, John R" sort="Wingard, John R" uniqKey="Wingard J" first="John R." last="Wingard">John R. Wingard</name>
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<placeName><region type="state">Floride</region>
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<author><name sortKey="Spellman, Stephen R" sort="Spellman, Stephen R" uniqKey="Spellman S" first="Stephen R." last="Spellman">Stephen R. Spellman</name>
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<author><name sortKey="Pavletic, Steven Z" sort="Pavletic, Steven Z" uniqKey="Pavletic S" first="Steven Z." last="Pavletic">Steven Z. Pavletic</name>
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<placeName><region type="state">Maryland</region>
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<wicri:cityArea>National Institutes of Health, National Cancer Institute, Bethesda</wicri:cityArea>
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</author>
<author><name sortKey="Lee, Stephanie J" sort="Lee, Stephanie J" uniqKey="Lee S" first="Stephanie J." last="Lee">Stephanie J. Lee</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff>
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<author><name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M." last="Horowitz">Mary M. Horowitz</name>
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<placeName><region type="state">Wisconsin</region>
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<author><name sortKey="Flowers, Mary E D" sort="Flowers, Mary E D" uniqKey="Flowers M" first="Mary E. D." last="Flowers">Mary E. D. Flowers</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">CIBMTR Chronic GVHD Risk Score Predicts Mortality in an Independent Validation Cohort</title>
<author><name sortKey="Arora, Mukta" sort="Arora, Mukta" uniqKey="Arora M" first="Mukta" last="Arora">Mukta Arora</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hemmer, Michael T" sort="Hemmer, Michael T" uniqKey="Hemmer M" first="Michael T." last="Hemmer">Michael T. Hemmer</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Center for International Blood & Marrow Transplantation Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood & Marrow Transplantation Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Center for International Blood & Marrow Transplantation Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood & Marrow Transplantation Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A3">Divison of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Divison of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Klein, John P" sort="Klein, John P" uniqKey="Klein J" first="John P." last="Klein">John P. Klein</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Center for International Blood & Marrow Transplantation Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood & Marrow Transplantation Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
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<affiliation wicri:level="2"><nlm:aff id="A3">Divison of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Divison of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cutler, Corey S" sort="Cutler, Corey S" uniqKey="Cutler C" first="Corey S." last="Cutler">Corey S. Cutler</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Dana-Farber Cancer Institute, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Dana-Farber Cancer Institute, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Urbano Ispizua, Alvaro" sort="Urbano Ispizua, Alvaro" uniqKey="Urbano Ispizua A" first="Alvaro" last="Urbano-Ispizua">Alvaro Urbano-Ispizua</name>
<affiliation wicri:level="3"><nlm:aff id="A5">Department of Hematology, Hospital Clinic, University of Barcelona, IDIBAPS, and Institute of Research Josep Carreras, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Hematology, Hospital Clinic, University of Barcelona, IDIBAPS, and Institute of Research Josep Carreras, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Couriel, Daniel R" sort="Couriel, Daniel R" uniqKey="Couriel D" first="Daniel R." last="Couriel">Daniel R. Couriel</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Blood and Marrow Transplant Program, University of Michigan, Ann Arbor, MI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Blood and Marrow Transplant Program, University of Michigan, Ann Arbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Alousi, Amin M" sort="Alousi, Amin M" uniqKey="Alousi A" first="Amin M." last="Alousi">Amin M. Alousi</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Stem Cell Transplant and Cellular Therapy, University of Texas, M.D. Anderson Cancer Center, Houston, TX</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Stem Cell Transplant and Cellular Therapy, University of Texas, M.D. Anderson Cancer Center, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name>
<affiliation wicri:level="3"><nlm:aff id="A8">Hematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Hematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name>
<affiliation wicri:level="3"><nlm:aff id="A9">National Cancer Center Hospital, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>National Cancer Center Hospital, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical Center, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Li, Peigang" sort="Li, Peigang" uniqKey="Li P" first="Peigang" last="Li">Peigang Li</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Center for International Blood & Marrow Transplantation Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood & Marrow Transplantation Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Antin, Joseph H" sort="Antin, Joseph H" uniqKey="Antin J" first="Joseph H." last="Antin">Joseph H. Antin</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Dana-Farber Cancer Institute, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Dana-Farber Cancer Institute, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bolwell, Brian J" sort="Bolwell, Brian J" uniqKey="Bolwell B" first="Brian J." last="Bolwell">Brian J. Bolwell</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Leukemia Program, Hematologic Oncology and Blood Disorders, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Leukemia Program, Hematologic Oncology and Blood Disorders, Cleveland Clinic Taussig Cancer Institute, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Boyiadzis, Michael" sort="Boyiadzis, Michael" uniqKey="Boyiadzis M" first="Michael" last="Boyiadzis">Michael Boyiadzis</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Cancer Center, University of Pittsburgh Medical Center, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
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<wicri:regionArea>Department of Hematology, University Hospital, Grenoble</wicri:regionArea>
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<author><name sortKey="Cairo, Mitchell S" sort="Cairo, Mitchell S" uniqKey="Cairo M" first="Mitchell S." last="Cairo">Mitchell S. Cairo</name>
<affiliation wicri:level="2"><nlm:aff id="A13">Department of Pediatric Hematology, Oncology, New York Medical College, Valhalla, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Pediatric Hematology, Oncology, New York Medical College, Valhalla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Isola, Luis M" sort="Isola, Luis M" uniqKey="Isola L" first="Luis M." last="Isola">Luis M. Isola</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Division of Blood and Marrow Transplantation, The Mount Sinai Medical Center, New York, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Division of Blood and Marrow Transplantation, The Mount Sinai Medical Center, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jacobsohn, David A" sort="Jacobsohn, David A" uniqKey="Jacobsohn D" first="David A." last="Jacobsohn">David A. Jacobsohn</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Divison of Blood and Marrow Transplantation Center for Cancer and Blood Disorders, Children's National Medical Center, Washington, DC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">District de Columbia</region>
</placeName>
<wicri:cityArea>Divison of Blood and Marrow Transplantation Center for Cancer and Blood Disorders, Children's National Medical Center, Washington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jagasia, Madan" sort="Jagasia, Madan" uniqKey="Jagasia M" first="Madan" last="Jagasia">Madan Jagasia</name>
<affiliation wicri:level="2"><nlm:aff id="A16">Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Klumpp, Thomas R" sort="Klumpp, Thomas R" uniqKey="Klumpp T" first="Thomas R." last="Klumpp">Thomas R. Klumpp</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Temple Bone Marrow Transplant Program, Philadelphia, PA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Temple Bone Marrow Transplant Program, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Petersdorf, Effie W" sort="Petersdorf, Effie W" uniqKey="Petersdorf E" first="Effie W." last="Petersdorf">Effie W. Petersdorf</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Santarone, Stella" sort="Santarone, Stella" uniqKey="Santarone S" first="Stella" last="Santarone">Stella Santarone</name>
<affiliation wicri:level="1"><nlm:aff id="A19">Ospedale Civile BMT Center, Pescara, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Ospedale Civile BMT Center, Pescara</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name>
<affiliation wicri:level="1"><nlm:aff id="A20">Department of Hematology, Academische Ziekenhuis Maastricht, Maastricht, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Hematology, Academische Ziekenhuis Maastricht, Maastricht</wicri:regionArea>
<wicri:noRegion>Maastricht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wingard, John R" sort="Wingard, John R" uniqKey="Wingard J" first="John R." last="Wingard">John R. Wingard</name>
<affiliation wicri:level="2"><nlm:aff id="A21">Division of Hematology & Onocology, Department of Medicine, Shands Cancer Center & University of Florida, Gainesville, FL</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Floride</region>
</placeName>
<wicri:cityArea>Division of Hematology & Onocology, Department of Medicine, Shands Cancer Center & University of Florida, Gainesville</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Spellman, Stephen R" sort="Spellman, Stephen R" uniqKey="Spellman S" first="Stephen R." last="Spellman">Stephen R. Spellman</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Center for International Blood & Marrow Transplantation Research, National Marrow Donor Program, Minneapolis, MN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Minnesota</region>
</placeName>
<wicri:cityArea>Center for International Blood & Marrow Transplantation Research, National Marrow Donor Program, Minneapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Pavletic, Steven Z" sort="Pavletic, Steven Z" uniqKey="Pavletic S" first="Steven Z." last="Pavletic">Steven Z. Pavletic</name>
<affiliation wicri:level="2"><nlm:aff id="A23">National Institutes of Health, National Cancer Institute, Bethesda, MD</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>National Institutes of Health, National Cancer Institute, Bethesda</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lee, Stephanie J" sort="Lee, Stephanie J" uniqKey="Lee S" first="Stephanie J." last="Lee">Stephanie J. Lee</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M." last="Horowitz">Mary M. Horowitz</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Center for International Blood & Marrow Transplantation Research, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>Center for International Blood & Marrow Transplantation Research, Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Flowers, Mary E D" sort="Flowers, Mary E D" uniqKey="Flowers M" first="Mary E. D." last="Flowers">Mary E. D. Flowers</name>
<affiliation wicri:level="2"><nlm:aff id="A18">Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea>
</affiliation>
</author>
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<series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title>
<idno type="ISSN">1083-8791</idno>
<idno type="eISSN">1523-6536</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Allografts</term>
<term>Chronic Disease</term>
<term>Cohort Studies</term>
<term>Disease-Free Survival</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Graft vs Host Disease (mortality)</term>
<term>Hematopoietic Stem Cell Transplantation</term>
<term>Humans</term>
<term>Incidence</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
<term>Risk Factors</term>
<term>Survival Rate</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Allogreffes</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Incidence</term>
<term>Maladie chronique</term>
<term>Maladie du greffon contre l'hôte (mortalité)</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Survie sans rechute</term>
<term>Taux de survie</term>
<term>Transplantation de cellules souches hématopoïétiques</term>
<term>Études de cohortes</term>
<term>Études de suivi</term>
<term>Études rétrospectives</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Graft vs Host Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Maladie du greffon contre l'hôte</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Allografts</term>
<term>Chronic Disease</term>
<term>Cohort Studies</term>
<term>Disease-Free Survival</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Hematopoietic Stem Cell Transplantation</term>
<term>Humans</term>
<term>Incidence</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
<term>Risk Factors</term>
<term>Survival Rate</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Allogreffes</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Incidence</term>
<term>Maladie chronique</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Survie sans rechute</term>
<term>Taux de survie</term>
<term>Transplantation de cellules souches hématopoïétiques</term>
<term>Études de cohortes</term>
<term>Études de suivi</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">We previously reported a risk score that predicted mortality in patients with chronic graft-versus-host disease (CGVHD) after hematopoietic stem cell transplant (HCT) between 1995–2004 and reported to the Center for International Blood and Marrow Transplant Registry (CIBMTR). We sought to validate this risk score in an independent CIBMTR cohort of 1128 patients with CGVHD transplanted between 2005–2007 using the same inclusion criteria and risk-score calculations. According to the sum of the overall risk score (range 1 to 12), patients were assigned to 4 risk-groups (RGs): RG1 (0–2), RG2 (3–6), RG3 (7–8) and RG4 (9–10). RG3 and 4 were combined as RG4 comprised only 1% of the total cohort. Cumulative incidences of non relapse mortality (NRM) and probability of overall survival (OS) were significantly different between each RG (all p<0.01). NRM and OS at five years after CGVHD for each RG were 17% and 72% in RG1, 26% and 53% in RG2, and 44% and 25% in RG 3, respectively (all p<0.01). Our study validates the prognostic value of the CIBMTR CGVHD RGs for OS and NRM in a contemporary transplant population. The CIBMTR CGVHD RGs can be used to predict major outcomes, tailor treatment planning, and enrollment in clinical trials.</p>
</div>
</front>
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<tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Arora, Mukta" sort="Arora, Mukta" uniqKey="Arora M" first="Mukta" last="Arora">Mukta Arora</name>
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<name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name>
<name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name>
<name sortKey="Alousi, Amin M" sort="Alousi, Amin M" uniqKey="Alousi A" first="Amin M." last="Alousi">Amin M. Alousi</name>
<name sortKey="Antin, Joseph H" sort="Antin, Joseph H" uniqKey="Antin J" first="Joseph H." last="Antin">Joseph H. Antin</name>
<name sortKey="Bolwell, Brian J" sort="Bolwell, Brian J" uniqKey="Bolwell B" first="Brian J." last="Bolwell">Brian J. Bolwell</name>
<name sortKey="Boyiadzis, Michael" sort="Boyiadzis, Michael" uniqKey="Boyiadzis M" first="Michael" last="Boyiadzis">Michael Boyiadzis</name>
<name sortKey="Cairo, Mitchell S" sort="Cairo, Mitchell S" uniqKey="Cairo M" first="Mitchell S." last="Cairo">Mitchell S. Cairo</name>
<name sortKey="Couriel, Daniel R" sort="Couriel, Daniel R" uniqKey="Couriel D" first="Daniel R." last="Couriel">Daniel R. Couriel</name>
<name sortKey="Cutler, Corey S" sort="Cutler, Corey S" uniqKey="Cutler C" first="Corey S." last="Cutler">Corey S. Cutler</name>
<name sortKey="Flowers, Mary E D" sort="Flowers, Mary E D" uniqKey="Flowers M" first="Mary E. D." last="Flowers">Mary E. D. Flowers</name>
<name sortKey="Hemmer, Michael T" sort="Hemmer, Michael T" uniqKey="Hemmer M" first="Michael T." last="Hemmer">Michael T. Hemmer</name>
<name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M." last="Horowitz">Mary M. Horowitz</name>
<name sortKey="Isola, Luis M" sort="Isola, Luis M" uniqKey="Isola L" first="Luis M." last="Isola">Luis M. Isola</name>
<name sortKey="Jacobsohn, David A" sort="Jacobsohn, David A" uniqKey="Jacobsohn D" first="David A." last="Jacobsohn">David A. Jacobsohn</name>
<name sortKey="Jagasia, Madan" sort="Jagasia, Madan" uniqKey="Jagasia M" first="Madan" last="Jagasia">Madan Jagasia</name>
<name sortKey="Klein, John P" sort="Klein, John P" uniqKey="Klein J" first="John P." last="Klein">John P. Klein</name>
<name sortKey="Klein, John P" sort="Klein, John P" uniqKey="Klein J" first="John P." last="Klein">John P. Klein</name>
<name sortKey="Klumpp, Thomas R" sort="Klumpp, Thomas R" uniqKey="Klumpp T" first="Thomas R." last="Klumpp">Thomas R. Klumpp</name>
<name sortKey="Lee, Stephanie J" sort="Lee, Stephanie J" uniqKey="Lee S" first="Stephanie J." last="Lee">Stephanie J. Lee</name>
<name sortKey="Li, Peigang" sort="Li, Peigang" uniqKey="Li P" first="Peigang" last="Li">Peigang Li</name>
<name sortKey="Pavletic, Steven Z" sort="Pavletic, Steven Z" uniqKey="Pavletic S" first="Steven Z." last="Pavletic">Steven Z. Pavletic</name>
<name sortKey="Petersdorf, Effie W" sort="Petersdorf, Effie W" uniqKey="Petersdorf E" first="Effie W." last="Petersdorf">Effie W. Petersdorf</name>
<name sortKey="Spellman, Stephen R" sort="Spellman, Stephen R" uniqKey="Spellman S" first="Stephen R." last="Spellman">Stephen R. Spellman</name>
<name sortKey="Weisdorf, Daniel J" sort="Weisdorf, Daniel J" uniqKey="Weisdorf D" first="Daniel J." last="Weisdorf">Daniel J. Weisdorf</name>
<name sortKey="Wingard, John R" sort="Wingard, John R" uniqKey="Wingard J" first="John R." last="Wingard">John R. Wingard</name>
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<country name="Espagne"><region name="Catalogne"><name sortKey="Urbano Ispizua, Alvaro" sort="Urbano Ispizua, Alvaro" uniqKey="Urbano Ispizua A" first="Alvaro" last="Urbano-Ispizua">Alvaro Urbano-Ispizua</name>
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</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Gale, Robert Peter" sort="Gale, Robert Peter" uniqKey="Gale R" first="Robert Peter" last="Gale">Robert Peter Gale</name>
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<country name="Japon"><region name="Région de Kantō"><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name>
</region>
</country>
<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
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<country name="Italie"><noRegion><name sortKey="Santarone, Stella" sort="Santarone, Stella" uniqKey="Santarone S" first="Stella" last="Santarone">Stella Santarone</name>
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</country>
<country name="Pays-Bas"><noRegion><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name>
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</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000271 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000271 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Amérique
   |area=    PittsburghV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     PMC:4359642
   |texte=   CIBMTR Chronic GVHD Risk Score Predicts Mortality in an Independent Validation Cohort
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/France/Analysis/RBID.i   -Sk "pubmed:25528390" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/France/Analysis/biblio.hfd   \
       | NlmPubMed2Wicri -a PittsburghV1

This area was generated with Dilib version V0.6.38.
Data generation: Fri Jun 18 17:37:45 2021. Site generation: Fri Jun 18 18:15:47 2021

Serveur d'exploration sur Pittsburgh

CIBMTR Chronic GVHD Risk Score Predicts Mortality in an Independent Validation Cohort

CIBMTR Chronic GVHD Risk Score Predicts Mortality in an Independent Validation Cohort

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English descriptors

Abstract

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Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur Pittsburgh
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.